HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → Dimethyl 3-(4-methoxycarbonylphenyl)-2-isoxazolin-5-ylphosphonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Chlorosuccinimide | HCID 31398 | — |
| Reactant | Dimethyl vinylphosphonate | HCID 78376 | — |
| Reactant | Methyl 4-(hydroxyamino)benzoate | HCID 11137507 | — |
| Product | Dimethyl 3-(4-methoxycarbonylphenyl)-2-isoxazolin-5-ylphosphonate | HCID 14460581 | — |
Reaction Steps
Reaction of 80.6 g (0.45 mol) of methyl 4-hydroxyaminobenzoate, 67.0 g (0.5 mol) of N-chlorosuccinimide, 61.25 g (0.45 mol) of dimethyl vinylphosphonate and 78.45 ml (0.56 mol) of triethylamine as in Example 1 provides, after recrystallization from tert.butyl methyl ether, 115.2 g of pure product of melting point 93° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05006515 |
| Source dataset | uspto-grants-1991_04 |
| ORD ID | ord-02d9460b3412401a8a35929ddf9a6867 |
| Source note | uspto-grants-1991_04 |