Potassium Hydroxide → HCID 20062742, compound

HRID 1084808Notes

Reaction equation

HRID 1084808 reaction equation
[OH-].[K+].[O:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](=[O:13])[CH2:5][CH2:4]1.[CH3:14][C:15]1[N:19]([C:20]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH:18]=[N:17][C:16]=1[CH:39]=O>CO>[CH3:14][C:15]1[N:19]([C:20]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)([C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)[C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[CH:18]=[N:17][C:16]=1/[CH:39]=[C:5]1\[CH2:4][O:3][C:12]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[C:6]\1=[O:13]

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 68110ChromanoneHCID 118243385-methyl-1-trityl-1H-imidazole-4-carbaldehyde

Product 1

HCID 20062742HCID 20062742, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

A solution of potassium hydroxide (0.5 g) in methanol (5 ml) was added to a solution of 4-chromanone (0.84 g) and 5-methyl-1-(triphenylmethyl)-1H-imidazole-4-carboxaldehyde (2 g) in methanol (25 ml) with warming, and the resulting solution was stirred at 50° for 3 h. The resultant precipitate was filtered off, washed with methanol (25 ml) and dried to give the title compound (2.6 g), m.p. 231°-233°.

Workup

  1. temperaturewith warming
  2. filtrationThe resultant precipitate was filtered off
  3. washwashed with methanol (25 ml)
  4. customdried

Sources & evidence

ORD record
ord-f59e68a8f32e465e99d7a7fdb85722b6
Source dataset
uspto-grants-1991_04
Patent number
US05006544

Reaction notes

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