Hydrochloric Acid → HCID 178520517, compound

Participants

Reaction Steps

Methyl 2-[3-(1-t-butoxycarbonyl-1H-imidazole-4-yl)acrylamido]benzoate (168 mg) was dissolved in methanol (9 ml), 3N.HCl (2 ml) was added. The mixture was stirred at room temperature for 1 hour. Then, methanol was removed and the precipitated solid were filtered. The solid were again dissolved in methanol (9 ml), and 1N-NaOH (0.9 ml) was added. The mixture was reacted with stirring at 70° C. for 1 hour. After removing methanol, the mixture was treated with water and slightly acidified by KHSO4 under ice cooling to give white solids of the title compound (88 mg, yield, 76%). m.p., 263°-265° C.

Provenance & Evidence