Butanethiol → 1-(3-hydroxyphenyl)-3-phenyl-1H-pyrazolo[3,4-b]pyridine

참여 물질

반응 단계

In 400 ml of dichloromethane was suspended 45.1 g of anhydrous aluminium chloride. While stirring, 45.1 ml of butylmercaptan was added thereto. After the mixture was stirred at room temperature for 1 hour, 34 g of 1-(3-methoxy- phenyl)-3-phenyl-1H-pyrazolo[3,4-b]pyridine was added under ice-cooling. The mixture was stirred at room temperature for 6 hours. The reaction mixture was poured into about 2 l of ice-water. The resulting crystals were collected by filtration, and washed with water to give 33.0 g of 1-(3-hydroxy- phenyl)-3-phenyl-1H-pyrazolo[3,4-b]pyridine, m.p. 142°-144° C.

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