Dimethylformamide → HCID 86744713, compound

Participants

Reaction Conditions

Reaction Steps

In 100 ml of dimethylformamide were suspended 7.0 g of 1-(4-hydroxyphenyl)-3-phenyl-1H-pyrazolo[3,4-b]pyridine, 3.6 g of 3-dimethylaminopropylchloride and 3.7 g of potassium carbonate. The mixture was stirred at 100° C. for 4 hours. After the solvent was distilled off under reduced pressure, the residue was extracted with chloroform-water. The organic layer was concentrated, and the residue was purified by silica gel column chromatography (eluent: chloroform : methanol=20:1). Thereafter, by adding maleic acid, the purified product was converted into the salt. The obtained crude crystals were recrystallized from ethyl acetate to give 7.2 g of 1-[4-(3-dimethylaminopropoxy)phenyl]-3-phenyl-1H-pyrazolo[3,4-b]pyridine·maleate, m.p. 133°-136° C.

Provenance & Evidence