Dimethylformamide → HCID 86744714, compound

Participants

Reaction Conditions

Reaction Steps

In 60 ml of dimethylformamide were suspended 4.0 g of 3-(4-bromophenyl)-1-(4-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridine, 1.8 g of 2-diethylaminoethylchloride and 1.7 g of potassium carbonate. The mixture was stirred at 100° C. for 6 hours. After the solvent was distilled off under reduced pressure, the residue was extracted with toluene-water. The organic layer was concentrated. By adding maleic acid, the residue was corverted into the salt. The obtained crude crystals were recrystallized from ethyl acetate to give 3.0 g of 3-(4-bromophenyl)-1-[4-(2-diethylaminoethoxy)phenyl]-1H-pyrazolo[3,4-b]pyridine·maleate, m.p. 135°-140° C.

Provenance & Evidence