Dimethylformamide → HCID 86744716, compound

Participants

Reaction Conditions

Reaction Steps

In 15 ml of dimethylformamide were suspended 4.5 g of 3-(4-hydroxyphenyl)-1-(4-methylphenyl)-1H-pyrazolo[3,4-b]pyridine, 2.2 g of 3-dimethylaminopropylchloride and 2.3 g of potassium carbonate. After the mixture was stirred at 100° C. for 4 hours, it was extracted with toluene-water. The organic layer was concentrated. By adding maleic acid to the residue, it was converted to the salt. The obtained crude crystals were recrystallized from ethanol to give 4.0 g of 3-[4-(3-dimethylaminopropoxy)phenyl]-1-(4-methylphenyl)-1H-pyrazolo[3,4-b]pyridine·maleate, m.p. 138°-140° C.

Provenance & Evidence