Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-Chloro-N,N-dimethyl-1-propanamine | HCID 66960 | — |
| Reactant | HCID 14796261 | HCID 14796261 | — |
| Product | HCID 86744717 | HCID 86744717 | — |
Reaction Steps
In 15 ml of dimethylformamide were suspended 5.3 g of 3-(4-fluorophenyl)-1-(3-hydroxyphenyl)-1H-indazole, 2.5 g of 3-dimethylaminopropylchloride and 2.7 g of potassium carbonate. The mixture was stirred at 100° C. for 4 hours, and then it was extracted with toluene-water. After the organic layer was concentrated, maleic acid was added to the residue to obtain the salt. The obtained crude crystals were recrystallized from ethyl acetate to give 5.0 g of 3-(4-fluorophenyl)-1-[3-(3-dimethylaminopropoxy)phenyl]-1H-indazole·maleate, m.p. 110°-112° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05006520 |
|---|
| Source dataset | uspto-grants-1991_04 |
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| ORD ID | ord-9631de0d9a3b4451b864bb2133c9ad77 |
|---|
| Source note | uspto-grants-1991_04 |
|---|
