Dimethylformamide → HCID 86744719, compound

Participants

Reaction Conditions

Reaction Steps

In 20 ml of dimethylformamide were suspended 6.0 g of 3-[4-(3-dimethylaminopropoxy)phenyl]-1H-pyrazolo[3,4-b]pyridine and 4.1 g of potassium carbonate. While the mixture was stirred under heating at 50° C., 3.9 g of 4-chlorobenzylchloride dissolved in 5 ml of toluene was added. After the mixture was stirred at 50° C. for 1 hour, the mixture was extracted with toluene-water. The organic layer was concentrated. By adding maleic acid to the residue, the salt was obtained. The obtained crude crystals were recrystallized from ethanol to give 4.5 g of 1-(4-chlorobenzyl)-3-[4-(3-dimethylaminopropoxy)phenyl]-1H-pyrazolo[3,4-b]pyridine·maleate, m.p. 136°-138° C.

Provenance & Evidence