Ethyl bromoacetate → HCID 14796395, compound

Participants

Reaction Conditions

Reaction Steps

In 400 ml of dimethylformamide were suspended 39.3 g of 3-(4-hydroxyphenyl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine, 34.4 g of ethyl bromoacetate and 28.4 g of potassium carbonate. The mixture was stirred under heating at 70° C. for 2 hours. The reaction mixture was concentrated under reduced pressure and the residue was extracted with benzene-water. The organic layer was concentrated. Hexane was added to the residue for crystallization. The obtained crude crystals were recrystallized from isopropyl ether to give 28 g of ethyl 4-(1-phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl)phenoxyacetate, m.p. 118°-120° C.

Provenance & Evidence