Sodium Hydroxide → HCID 14796406, compound

HRID 1084852Notes

Reaction equation

HRID 1084852 reaction equation
[CH3:1][N:2]([CH3:27])[CH2:3][CH2:4][NH:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[C:20]3[C:15](=[N:16][CH:17]=[CH:18][CH:19]=3)[N:14]([CH2:21][C:22]([O:24]CC)=[O:23])[N:13]=2)=[CH:8][CH:7]=1.[OH-].[Na+]>>[CH3:1][N:2]([CH3:27])[CH2:3][CH2:4][NH:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[C:20]3[C:15](=[N:16][CH:17]=[CH:18][CH:19]=3)[N:14]([CH2:21][C:22]([OH:24])=[O:23])[N:13]=2)=[CH:8][CH:7]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 15158100HCID 15158100, compound

Product 1

HCID 14796406HCID 14796406, compound

Procedure

By conducting reactions and treatments in the same manner as in Example 66 (3), using 4.6 g of ethyl 3-[4-(2dimethylaminoethylamino)phenyl]-1H-pyrazolo[3,4-b]pyridin-1-ylacetate and 0.65 g of sodium hydroxide and recrystallizing from hydrous methanol, there was obtained 3-[4-(2-dimethylaminoethylamino)phenyl]-1H-pyrazolo[3,4-b]pyridin-1-ylacetic acid, m.p. 240°-242° C.

Workup

  1. customrecrystallizing from hydrous methanol

Sources & evidence

ORD record
ord-4f397b0392714c1db56ae2cbea5e8ce6
Source dataset
uspto-grants-1991_04
Patent number
US05006520

Reaction notes

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