3-Methyl-4-allyloxy-7-(2-thienoyl)benzofuran → 3-Methyl-4-hydroxy-5-propyl-7-(2-thienoyl)benzofuran

Participants

Reaction Steps

A mixture of 3-methyl-4-hydroxy-5-(2-propen-1-yl)-7-(2-thienoyl)benzofuran, compound 4 (0.228 g, 0.76 mmol) and 5% Pd/C (0.020 g) in absolute ethanol (5 mL) was hydrogenated at 3 atmospheres pressure. After 0.5 hours the requisite amount of hydrogen had been taken up. The catalyst was removed by filtration through celite and the filtrate concentrated to an oil that slowly solidified. Recrystallization of this material from ether/hexane afforded pure 3-methyl-4-hydroxy-5-propyl-7-(2-thienoyl)benzofuran, compound 5 as an off white solid. 1H NMR d 0.98 (3H, t, J=8 Hz), 1.67 (2H, m), 2.40 (3H, s), 2.64 (2H, t, J=6 Hz), 7.14 (1H, m), 7.30 (1H, s), 7.48 (1H, s), 7.63 (1H, d, J=4 Hz), 7.68 (1H, d, J= 4 Hz).

Provenance & Evidence