Water → HCID 15124011, compound

Participants

Reaction Steps

Ethyl 3-methyl-4-hydroxy-7-tert-butylbenzofuran (0.405 g, 1.47 mmol) was saponified in a solution of KOH (0.247 g, 4.41 mmol) in refluxing water (10 mL) for two hours. Acidification of the cooled mixture led to precipitation of the product. 3-Methyl-4-hydroxy-7-tert-butylbenzofuran-2-carboxylic acid, compound 8, was collected by filtration and vacuum dried. This material was decarboxylated without further purification, mp 219°-222° C.; 1H NMR (DMSO-d6) d 1.38 (9H, s), 2.64 (3H, s), 6.55 (1H, d, J=8 Hz), 7.07 (1H, d, J=8 Hz), 9.66 (1H, s).

Provenance & Evidence