Potassium Hydroxide → HCID 15124012, compound

Participants

Reaction Steps

Ethyl 3-methyl-4-hydroxy-5,7-di-tert-butylbenzofuran-2-carboxylate (0.475 g, 1.43 mmol) was refluxed in a solution of KOH (0.241 g, 4.29 mmol) in water (10 mL) and methanol (2 mL) for two hours. Acidification of the cooled mixture led to precipitation of the product. 3-Methyl-4-hydroxy-5,7-di-tert-butylbenzofuran-2-carboxylic acid, compound 9, was collected by filtration and vacuum dried. This material was decarboxylated without further purification. mp 241°-243° C.; 1H NMR (DMSO-d6) d 1.40 (18H, s), 2.71 (3H, s), 7.18 (1H, s), 8.35 (1H, s).

Provenance & Evidence