Nitric Acid → HCID 14835241, compound

Participants

Reaction Steps

2-[N-Methyl-N-(4-nitrophenethyl)amino]indane hydrochloride (1.2 g) was added portionwise over 10 minutes to fuming nitric acid (20 ml, density=1.5 g/ml) cooled to -5°. Stirring was continued for a further 2 minutes before the reaction mixture was poured into ice/water. The water-containing mixture was extracted with methylene chloride and the organic extract was washed with aqueous sodium bicarbonate, dried (MgSO4) and evaporated to dryness in vacuo. The residue was rectystallised from ethanol to give the title compound, yield 0.78 g, m.p. 138°-140°.

Provenance & Evidence