Chlorosulfonic acid → HCID 13983503, compound

HRID 1084921Notes

Reaction equation

HRID 1084921 reaction equation
[Cl:1][S:2]([OH:5])(=O)=[O:3].[CH3:6][CH:7]1[CH2:11][C:10]2[CH:12]=[CH:13][CH:14]=[C:15]([C:16]([OH:18])=[O:17])[C:9]=2[O:8]1>>[Cl:1][S:2]([C:13]1[CH:14]=[C:15]([C:16]([OH:18])=[O:17])[C:9]2[O:8][CH:7]([CH3:6])[CH2:11][C:10]=2[CH:12]=1)(=[O:5])=[O:3]

Participants

3

Reactant 2

HCID 24638Chlorosulfonic acidHCID 983082-Methyl-2,3-dihydro-1-benzofuran-7-carboxylic acid

Product 1

HCID 13983503HCID 13983503, compound

Conditions

Temperature
0 °C

Procedure

630 g of chlorosulphonic acid were introduced into a 1-liter round-bottomed flask. The contents were cooled to 0° C. and 160 g of finely ground 2-methyl-2,3-dihydrobenzofuran-7-carboxylic acid were then added in portions, maintaining the temperature between 0° and 5° C. by cooling in an ice bath.

Workup

  1. temperaturemaintaining the temperature between 0° and 5° C.
  2. temperatureby cooling in an ice bath

Sources & evidence

ORD record
ord-c68f31e96895409894500206cf2857d8
Source dataset
uspto-grants-1991_04
Patent number
US05006570

Reaction notes

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