Acetic Acid → 6-Mercaptochroman-8-carboxylic acid

Participants

Reaction Conditions

Reaction Steps

238 g of 6-chlorosulphonylchroman-8- carboxylic acid and 645 ml of acetic acid were introduced into a 6-liter round-bottomed flask. The mixture was heated to 80° C. and 384 g of tin was added and the mixture was then cooled to 50° C. 1720 ml of hydrochloric acid (d=1.18) were then poured in dropwise, while maintaining the temperature between 55° and 60° C. first by cooling in an ice bath and then by heating in a water bath. Heating was then continued for 3 hours at 60° C. and the solution was poured into 6 liters of water. The precipitate formed was drained, washed with 1 liter of dilute hydrochloric acid followed by water and then air-dried.

Provenance & Evidence