Methylamine → HCID 13983539, compound

Participants

Reaction Conditions

Reaction Steps

70 g of methylamine in a 40% aqueous solution and 70 ml of water were introduced into a 1-liter round-bottomed flask. The contents were cooled to 0° C. and 160 g of 5-bromo-6-chlorosulphonylchroman-8-carboxylic acid were added in 16 g portions, the introduction of each portion of acid being followed by the addition of 18 ml of a solution containing 90 ml of 30% sodium hydroxide in 90 ml of water. The temperature was maintained between 0° and 5° C. during the entire period of introduction and for a further period of one hour. The temperature was then allowed to rise. The solution obtained was taken up with 1 liter of water, filtered with charcoal and acidified with concentrated hydrochloric acid until a color change of Congo red was observed.

Provenance & Evidence