Carbon Dioxide → HCID 13983542, compound

Participants

Reaction Conditions

Reaction Steps

220 ml of water, 47 g of sodium sulphite and 62.5 g of sodium bicarbonate were introduced into a 2-liter round-bottomed flask and the contents were then heated to 70° C. 76 g of 5-chlorosulphonyl-4-methoxy-2-methyl-2,3-dihydrobenzofuran-7-carboxylic acid were then added in small amounts. Heating was maintained at 70°-80° C. for 1 hour 30 minutes, until the evolution of carbon dioxide was complete. The contents were then cooled to 20° C. and 256 ml of ethanol, 49.5 ml of 30% sodium hydroxide and 116 g of ethyl iodide were then added. The contents were heated under reflux for 30 hours, the losses of ethyl iodide being replenished and the pH being readjusted by adding sodium hydroxide as soon as the medium was no longer alkaline.

Provenance & Evidence