HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-bromobutanimide → 2-(Bromomethyl)-6-chloro-pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 6-Chloro-2-picoline | HCID 87601 | — |
| Catalyst | Benzoyl Peroxide | HCID 7187 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Product | 2-(Bromomethyl)-6-chloro-pyridine | HCID 22032737 | 77.2% |
Reaction Steps
6-Chloro-2-methylpyridine (20 g), (Ex Aldrich), N-bromosuccinimide (31 g), benzoyl peroxide (570 mg) and tetrachloromethane (250 ml) were heated together under reflux and under irradiation from a powerful lamp for 6 hours. After standard work-up and purification by column chromatography (silica; 5% ether in hexane), 6-chloro-2-bromomethylpyridine (25 g,) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05006658 |
| Source dataset | uspto-grants-1991_04 |
| ORD ID | ord-b85bafecff494d58ba8f74cf445ee920 |
| Source note | uspto-grants-1991_04 |