2(RS)-[[(RS)-(methoxy)(phthalimidomethyl)phosphinyl]methyl]-4-methylvaleric acid → HCID 178502931, compound

HRID 1084998Notes

Reaction equation

HRID 1084998 reaction equation
[CH3:1][O:2][P:3](CC(CC(C)C)C(O)=O)([CH2:5][N:6]1[C:10](=[O:11])[C:9]2=[CH:12][CH:13]=[CH:14][CH:15]=[C:8]2[C:7]1=[O:16])=[O:4].NC1CCCCCCCCCCC(=O)N1>>[CH3:1][O:2][PH:3]([CH2:5][N:6]1[C:10](=[O:11])[C:9]2=[CH:12][CH:13]=[CH:14][CH:15]=[C:8]2[C:7]1=[O:16])=[O:4]

Participants

3

Reactant 2

HCID 200630192(RS)-[[(RS)-(methoxy)(phthalimidomethyl)phosphinyl]methyl]-4-methylvaleric acidHCID 21939029(-)-3-Amino-2-azacyclotridecanone

Product 1

HCID 178502931HCID 178502931, compound

Procedure

In an analogous manner to that described in Example 1(A)(iv), from 0.367 g of 2(RS)-[[(RS)-(methoxy)(phthalimidomethyl)phosphinyl]methyl]-4-methylvaleric acid and 0.2 g of (-)-3-amino-2-azacyclotridecanone there was obtained 0.21 g of [(RS)-4-methyl-2-[[(R or S) -2-oxoazacyclotridecyl]carbamoyl]pentyl](phthalimidomethyl)phosphinic acid methyl ester in the form of a white solid.

Sources & evidence

ORD record
ord-d1364b3c0724428a9ab5b83c0cc9bd2a
Source dataset
uspto-grants-1991_04
Patent number
US05006651

Reaction notes

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