Picolyl chloride hydrochloride → 6-Methyl-3-phenyl-2-(2-pyridylmethylthio)-4(3H)-quinazolinone

Participants

Reaction Steps

9.5 ml of 28% methanolic solution of sodium methoxide were added to a solution of 6.0 g of 2-mercapto-6-methyl-3- phenyl-4(3H)-quinazolinone and 4.0 g of 2-chloromethylpyridine hydrochloride in methanol, the mixture was stirred at room temperature for 2 hours and allowed to stand overnight. Crystals precipitated were collected by filtration and recrystallized from ethyl acetate to give 4.2 g (52.2%) of the title compound.

Provenance & Evidence