Ethylene Glycol → HCID 135621416, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 20 parts of 2-pyridinemethanamine, 37 parts of intermediate 1,200 parts of 1,2-ethanediol and 1.05 parts of acetic acid was stirred for 4 hours at 160° C. After cooling, the mixture was stirred in water, which was slightly basified with ammonium hydroxide. The whole was extracted with trichloromethane. The aqueous layer was evaporated and the residual oil was stirred with some 2-propanol for 1 hour. The product was filtered off, washed with 2-propanol and dried, yielding 21 parts (44.1%) of 5-(2-hydroxyethyl)-6-methyl-2-[(2-pyridinylmethyl)amino]-4(3H)-pyrimidinone; mp.-185° C. (interm. 21).

Provenance & Evidence