HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Iodide → HCID 15671927, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | 1-Azabicyclo[2.2.2]octane-4-carboxamide | HCID 10130069 | — |
| Reactant | (4-Methoxyphenyl)methyl (6R,7R)-3-(chloromethyl)-8-oxo-7-((2-phenylacetyl)amino)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate | HCID 10874591 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | HCID 15671927 | HCID 15671927 | 33.9% |
Reaction Steps
p-Methoxybenzyl 7β-phenylacetamido-3-chloromethyl-3-cephem-4-carboxylate (980 mg) was suspended in acetone (20 ml), and sodium iodide (362 mg) was added to the suspension and stirred at room temperature for 1 hour. To the resulting suspension was added 4-carbamoylquinuclidine (313 mg) under ice-cooled condition, and the mixture was stirred for 2 hours. The reaction mixture was filtered, and diethyl ether (70 ml) was added to the filtrate. The deposited solid was filtered to obtain the desired product (500 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05008260 |
| Source dataset | uspto-grants-1991_04 |
| ORD ID | ord-8ca7a035bbee4429a6a2c2caf85faf1b |
| Source note | uspto-grants-1991_04 |