Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → HCID 15671929, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | 1-Azabicyclo[2.2.2]octane-4-carboxamide | HCID 10130069 | — |
| 반응물 | HCID 14621642 | HCID 14621642 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | Diisopropyl Ether | HCID 7914 | — |
| 생성물 | HCID 15671929 | HCID 15671929 | 196.1% |
반응 단계
To an ethyl acetate solution (465 ml) of p-methoxybenzyl 7β-formamido-3-iodomethyl-3-cephem-4-carboxylate (9.3 g) there was added dropwise over 1 hour under stirring while ice-cooling a mixed solution (176 ml) of methanol and ethyl acetate (1:4 v/v) containing 4-carbamoyl quinuclidine (2.94 g). After stirring for 30 minutes, the resulting precipitate was collected by filtration, followed by washing with ethyl acetate and then diisopropyl ether to obtain the desired product (12.0 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05008260 |
| 출처 데이터셋 | uspto-grants-1991_04 |
| ORD ID | ord-87cd02c953c34862998788ad1e64f553 |
| 출처 메모 | uspto-grants-1991_04 |