4-Bromophthalic anhydride → HCID 21982189, compound

HRID 10851Notes

Reaction equation

HRID 10851 reaction equation
[NH2:1][CH2:2][CH:3]([C:8]1([CH3:13])[O:12][CH2:11][CH2:10][O:9]1)[C:4]([O:6][CH3:7])=[O:5].[Br:14][C:15]1[CH:16]=[C:17]2[C:22](=O)[O:21][C:19](=[O:20])[C:18]2=[CH:24][CH:25]=1>>[Br:14][C:15]1[CH:16]=[C:17]2[C:18](=[CH:24][CH:25]=1)[C:19](=[O:20])[N:1]([CH2:2][CH:3]([C:8]1([CH3:13])[O:9][CH2:10][CH2:11][O:12]1)[C:4]([O:6][CH3:7])=[O:5])[C:22]2=[O:21]

Participants

3

Reactant 2

HCID 665904-Bromophthalic anhydrideHCID 21982209Methyl 3-amino-2-(2-methyl-[1,3]dioxolan-2-yl)propionate

Product 1

HCID 21982189HCID 21982189, compound

Procedure

Methyl 3-(5-bromo-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-(2-methyl-[1,3]dioxolan-2-yl)propionate was prepared (0.48 g, 57 mmol) in the same manner as described in the above example 5 (1) from methyl 3-amino-2-(2-methyl-[1,3]dioxolan-2-yl)propionate (0.62 g, 2.75 mmol) and 4-bromophthalic anhydride (0.62 g, 2.75 mmol), and the obtained product was identified with the following NMR data.

Sources & evidence

ORD record
ord-0aca16acb83b4339af15f31b931fbbf8
Source dataset
uspto-grants-2006_08
Patent number
US07094908B2

Reaction notes

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