HuagongsheHuagongshe Chemistry Print Report · For research reference only
Riluzole → HCID 67922423, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Riluzole | HCID 5070 | — |
| Reactant | 2-Chloroethyl n-propyl sulfide | HCID 246203 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | HCID 67922423 | HCID 67922423 | 38.8% |
Reaction Steps
A mixture of 2-amino-6-trifluoromethoxybenzothiazole (9.4 g) and 1-chloro-2-propylthioethane (6.1 g) in methyl ethyl ketone (30 cc) is heated for 72 hours to boiling. The precipitate formed is filtered off, washed with methyl ethyl ketone (2×20 cc) and recrystallized in 2-propanol (30 cc). 2-Imino-3-(2-propylthioethyl)-6-trifluoromethoxybenzothiazoline hydrochloride (5.8 g), m.p. 187° C., is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05008280 |
| Source dataset | uspto-grants-1991_04 |
| ORD ID | ord-3a7084c509b647a09bb6f18b5234fec2 |
| Source note | uspto-grants-1991_04 |