HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1085126Generated: October 25, 2026
Riluzole → 3(2H)-Benzothiazoleethanol, 2-imino-6-(trifluoromethoxy)-, monohydrobromide
https://huagongshe.com/reaction/1085126
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Riluzole | HCID 5070 | — |
| Reactant | 2-Bromoethanol | HCID 10898 | — |
| Reactant | 3-(2-Hydroxyethyl)-2-imino-6-trifluoromethoxybenzothiazoline | HCID 3076252 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3(2H)-Benzothiazoleethanol, 2-imino-6-(trifluoromethoxy)-, monohydrobromide | HCID 3076251 | — |
Reaction Steps
3-(2-Hydroxyethyl)-2-imino-6-trifluoromethoxybenzothiazoline may be prepared in the following manner: 2-amino-6-trifluoromethoxybenzothiazole (9.4 g) and 2-bromoethanol (10 g) in absolute ethanol (30 cc) are heated for 95 hours to boiling. The mixture is cooled to a temperature in the region of 20° C. The precipitate formed is filtered off and washed with ethyl ether (100 cc). 3-(2-Hydroxyethyl)-2-imino-6-trifluoromethoxybenzothiazoline hydrobromide (6.4 g), m.p. 219° C., is thereby obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05008280 |
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| Source dataset | uspto-grants-1991_04 |
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| ORD ID | ord-93dd34b74fbb4f82beac53e36185ee27 |
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| Source note | uspto-grants-1991_04 |
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