Hydrochloric Acid → HCID 20061003, compound

Participants

Reaction Steps

A solution of 8,9-dimethyl-5-[4-(2-methylimidazo[4,5-c]pyrid-1-yl)phenyl]-4H-imidazo[1,2-a][1,5]-benzodiazepine (100 mg, 0.24 mmol) in dichloromethane was stirred with an excess of ethereal hydrogen chloride until precipitation was complete. The solid was filtered and dissolved in dry methanol (5 ml) to which was added sodium cyanoborohydride (20 mg 0.32 mmol). After stirring for 16 hours, the solution was acidified with dilute hydrochloric acid then adjusted to pH 8 by addition of sodium bicarbonate solution. The mixture was extracted with ethyl acetate which was dried over magnesium sulphate. Evaporation left a colourless gum.

Provenance & Evidence