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温度

0 °C

A mixture of 4-(2-methylimidazo[4,5-c]pyrid-1-yl)benzonitrile (12.0 g, 51.3 mmol) and 40% aqueous sodium hydroxide (55 ml) in absolute ethanol (55 ml) was heated at reflux for 11/2 hours. The solvent was removed under reduced pressure, and the brown residue was dissolved in water. The solution was chilled to 0° C. by the addition of ice. Glacial acetic acid (ca 33 ml) was added slowly. The buff solid which precipitated was filtered off, washed with water, and dried in vacuo at 70° C. Yield 9.14 g (70%).

1. temperaturewas heated
2. temperatureat reflux for 11/2 hours
3. customThe solvent was removed under reduced pressure
4. dissolutionthe brown residue was dissolved in water
5. additionGlacial acetic acid (ca 33 ml) was added slowly
6. customThe buff solid which precipitated
7. filtrationwas filtered off
8. washwashed with water
9. customdried in vacuo at 70° C