Nicotinic Acid → Ethyl 2-(2-methylimidazo[4,5-c]pyrid-1-yl)pyrid-5-oylacetate

HRID 1085147Notes

Reaction equation

HRID 1085147 reaction equation
[CH2:1]([O:3][C:4]([C:6]1C=CC(N2C3C=CN=CC=3N=C2C)=NC=1)=[O:5])[CH3:2].N1C=CC=C(C(O)=O)C=1.[CH3:31][C:32]1[N:33]([C:41]2[N:46]=[CH:45][C:44]([C:47]([OH:49])=O)=[CH:43][CH:42]=2)[C:34]2[CH:39]=[CH:38][N:37]=[CH:36][C:35]=2[N:40]=1.CC1N(C2C=CC(C(O)=O)=CC=2)C2C=CN=CC=2N=1>>[CH3:31][C:32]1[N:33]([C:41]2[CH:42]=[CH:43][C:44]([C:47]([CH2:6][C:4]([O:3][CH2:1][CH3:2])=[O:5])=[O:49])=[CH:45][N:46]=2)[C:34]2[CH:39]=[CH:38][N:37]=[CH:36][C:35]=2[N:40]=1

Participants

5

Reactant 4

HCID 938Nicotinic AcidHCID 104674374-(2-Methyl-1H-imidazo[4,5-C]pyridin-1-YL)benzoic acidHCID 198771831-(5-Ethoxycarbonylpyrid-2-yl)-2-methylimidazo[4,5-c]pyridineHCID 198771866-(2-Methylimidazo[4,5-c]pyrid-1-yl)pyridine-3-carboxylic acid

Product 1

HCID 54245582Ethyl 2-(2-methylimidazo[4,5-c]pyrid-1-yl)pyrid-5-oylacetate

Procedure

The method of Preparation 1, Method C, (b) was followed substituting the pyridine-3-carboxylic acid from (c) above for 4-(2-methylimidazo[4,5-c]pyrid-1-yl)benzoic acid. The title compound was an orange gum.

Sources & evidence

ORD record
ord-c1e2f1c25c644fe780828d9ca397aadc
Source dataset
uspto-grants-1991_04
Patent number
US05008263

Reaction notes

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