Hydrazine hydrate (1:1) → HCID 20060998, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 7,8-dichloro-2,3-dihydro-4-[4-(2-methylimidazo[4,5-c]pyrid-1-yl)phenyl]-1H-[1,5]benzodiazepin-2-thione (452 mg, 1.0 mmol), hydrazine hydrate (100 mg, 2 mmol) and red mercuric oxide (217 mg, 1.0 mmol) in n-butanol was heated at 100° C. for 30 minutes. The mixture was diluted with methanol (300 ml), filtered through Arbocel filter aid and the filtrate was concentrated under reduced pressure. The crude product was used directly for Example 32.

Provenance & Evidence