HCID 18769508, compound → 4,5-Diamino-3-methyl-1H-pyrazole-1-ethanol

HRID 1085154Notes

Reaction equation

HRID 1085154 reaction equation
[NH2:1][C:2]1[N:6]([CH2:7][CH2:8][OH:9])[N:5]=[C:4]([CH3:10])[C:3]=1[N:11]=O>C(O)C.ClCCl.[Pd]>[NH2:11][C:3]1[C:4]([CH3:10])=[N:5][N:6]([CH2:7][CH2:8][OH:9])[C:2]=1[NH2:1]

Participants

5

Reactant 1

HCID 18769508HCID 18769508, compound

Product 1

HCID 101978014,5-Diamino-3-methyl-1H-pyrazole-1-ethanolYield 97%

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 702EthanolSolventHCID 6344DichloromethaneSolvent

Procedure

5-Amino-1-(2-hydroxyethyl)-3-methyl-4-nitrosopyrazole (0.9 g, 5.3 mmole) was dissolved in a mixture of ethanol (40 ml) and dichloromethane (40 ml) and hydrogenated over 10% Pd/C (0.1 g) at 20 p.s.i. and 20° C. for 2 hours. The catalyst was filtered onto Arbocel and the solvent removed under reduced pressure yielding the title compound as a foam (800 mg, 97%).

Workup

  1. filtrationThe catalyst was filtered onto Arbocel
  2. customthe solvent removed under reduced pressure

Sources & evidence

ORD record
ord-14456989af0249a0a6e2a7357d5116a5
Source dataset
uspto-grants-1991_04
Patent number
US05008263

Reaction notes

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