HCID 15731546, compound → HCID 15731550, compound

HRID 1085160Notes

Reaction equation

HRID 1085160 reaction equation
[NH2:1][C:2]1[N:6]([CH3:7])[N:5]=[C:4]([C:8]2[S:9][CH:10]=[CH:11][CH:12]=2)[C:3]=1[N:13]=O>C(O)C.[Pd]>[NH2:13][C:3]1[C:4]([C:8]2[S:9][CH:10]=[CH:11][CH:12]=2)=[N:5][N:6]([CH3:7])[C:2]=1[NH2:1]

Participants

4

Reactant 1

HCID 15731546HCID 15731546, compound

Product 1

HCID 15731550HCID 15731550, compoundYield 97%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A suspension of 5-amino-4-nitroso-1-methyl-3-(2-thienyl)-pyrazole (1.255 g, 6.03 mmol) in ethanol (90 ml) was hydrogenated at 20 p.s.i. over 10% palladium on carbon (130 mg) at room temperature for 2 hours. The mixture was filtered through Arbocel filter aid and the filtrate was concentrated under reduced pressure to give the title compound as a red-brown solid (1.133 g, 97%), m.p. 154°-155° C.

Workup

  1. filtrationThe mixture was filtered through Arbocel
  2. filtrationfilter aid
  3. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-dd5695f5e65c47f9bc7fa4b33cba3835
Source dataset
uspto-grants-1991_04
Patent number
US05008263

Reaction notes

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