Methylamine → HCID 20061012, compound

Participants

Reaction Steps

Gaseous methylamine was bubbled through a suspension of 2-chloro-3-nitroquinoline (1.06 g, 5.1 mmol) in ethanol (20 ml) at 0° C. for 15 minutes. The solvent was removed under reduced pressure and the bright red residue was dissolved in dichloromethane (100 ml) and washed with saturated aqueous sodium bicarbonate (50 ml). The organic layer was dried (MgSO4) and concentrated under reduced pressure to give 2-methylamino-3-nitroquinoline (940 mg, 91%) as a red solid, m.p. 160° C.

Provenance & Evidence