Sodium Hydroxide → HCID 20061667, compound

HRID 1085221Notes

Reaction equation

HRID 1085221 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][CH2:12][CH2:13][C:14]2[N:15]([CH3:25])[C:16]([CH2:19][C:20]([O:22]CC)=[O:21])=[CH:17][CH:18]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[OH-].[Na+]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][CH2:12][CH2:13][C:14]2[N:15]([CH3:25])[C:16]([CH2:19][C:20]([OH:22])=[O:21])=[CH:17][CH:18]=2)(=[O:9])=[O:10])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 54187262HCID 54187262, compound

Product 1

HCID 20061667HCID 20061667, compound

Procedure

0.5 g (1.3 mmol) of ethyl [2-(2-(4-fluorobenzenesulphonylamino)-ethyl)-1-methylpyrrol-5-yl]acetate are stirred into 4.5 ml of 1N sodium hydroxide solution overnight at ambient temperature. The mixture is then extracted with ethylene chloride and the aqueous phase is acidified with 1N hydrochloric acid. The precipitate obtained is suction filtered and dried.

Workup

  1. extractionThe mixture is then extracted with ethylene chloride
  2. customThe precipitate obtained
  3. filtrationfiltered
  4. customdried

Sources & evidence

ORD record
ord-4819189f37074209b920c04667ea3c7c
Source dataset
uspto-grants-1991_04
Patent number
US05008290

Reaction notes

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