Triethylamine → HCID 20061283, compound

Participants

Reaction Steps

Next, to 150 ml of dioxane were added 4.88 g of the above prepared p-nitrophenacyl bromide, 4.48 g of 1,3-dimethyl-6-(1-piperazinyl)-2,4(1H,3H)-pyrimidinedione (compound 37) and 4.2 ml of triethylamine, and the solution was heated under reflux for 1 hour. Afterward, the reaction mixture was cooled to deposit crystals, and the latter were collected by filtration, dissolved in chloroform, washed with water, and dried (over anhydrous sodium sulfate). Afterward, the used solvent was distilled off, and methanol was then added to the residue so as to crystallize it. The resulting crystals were then collected by filtration, washed, and dried to obtain 4.02 g of 1,3-dimethyl-6-[4-(4-nitrophenacyl)piperazin-1-yl]-2,4(1H,3H)-pyrimidinedione (compound 43).

Provenance & Evidence