HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Nitrophenol → 1,3-dimethyl-6-{4-[2-(4-nitrophenoxy)ethyl]piperazin-1-yl}-2,4(1H,3H)-pyrimidinedione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Nitrophenol | HCID 980 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 1,3-dimethyl-6-[4-(2-hydroxyethyl)piperazin-1-yl]-2,4(1H,3H)-pyrimidinedione | HCID 9970252 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1,3-dimethyl-6-{4-[2-(4-nitrophenoxy)ethyl]piperazin-1-yl}-2,4(1H,3H)-pyrimidinedione | HCID 10091726 | 69.3% |
Reaction Steps
To 100 ml of anhydrous tetrahydrofuran were added 5.37 g of 1,3-dimethyl-6-[4-(2-hydroxyethyl)piperazin-1-yl]-2,4(1H,3H)-pyrimidinedione (compound 41), 3.20 g of 4-nitrophenol and 6.03 g of triphenylphosphine, and the resulting mixture was treated in the same manner as in Example 20-(2) to obtain 5.40 g of crystalline 1,3-dimethyl-6-{4-[2-(4-nitrophenoxy)ethyl]piperazin-1-yl}-2,4(1H,3H)-pyrimidinedione.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05008267 |
| Source dataset | uspto-grants-1991_04 |
| ORD ID | ord-1958cb8b37bf4df2bb436844cff5350a |
| Source note | uspto-grants-1991_04 |