4-Chloro-2-nitrophenol → HCID 19012033, compound

Participants

Reaction Steps

Preparation of 1,3-dimethyl-6-{4-[3-(4-chloro-2-nitrophenoxy)propyl]piperazin-1-yl}-2,4(1H,3H)-pyrimidinedione hydrochloride (Compound 140) ##STR125## 0.80 g of 4-chloro-2-nitrophenol, 1.13 g of 1,3-dimethyl-6-[4-(3-hydroxypropyl)piperazin-1-yl}-2,4(1H,3H)-pyrimidinedione (Compound 139) and 1.21 g of triphenylphosphine were suspended in 15 ml of anhydrous tetrahydrofuran, followed by the addition of 0.80 g of diethyl azodicarboxylate. The resultant mixture was treated in a similar manner to Example 84-(2), thereby obtaining 1.43 g of 1,3-dimethyl-6-{4-[3-(4-chloro-2-nitrophenyloxy)propyl]piperazin-1-yl}-2,4(1H,3H)-pyrimidinedione as crystals.

Provenance & Evidence