Triphenylphosphine → HCID 20061223, compound

Participants

Reaction Steps

Preparation of 1,3-dimethyl-6-{4-[3-(2-methoxy-5-nitrophenyloxy)propyl]piperazin-1-yl}-2,4(1H,3H)-pyrimidinedione hydrochloride (Compound 160) ##STR141## 0.9 g of 2-methoxy-5-nitrophenol, 1.0 g of 1,3-dimethyl-6-[4-(3-hydroxypropyl)piperazin-1-yl]-2,4(1H,3H)-pyrimidinedione (Compound 139) and 1.1 g of triphenylphosphine were suspended in 20 ml of anhydrous tetrahydrofuran, followed by the addition of 0.67 ml of diethyl azodicarboxylate. The thus-prepared mixture was treated in a similar manner to Example 84-(2), thereby obtaining 1.2 g of 1,3-dimethyl-6-{4-[3-(2-methoxy-5-nitrophenyloxy)propyl]piperazin-1-yl}-2,4(1H,3H)-pyrimidinedione as an oily substance.

Provenance & Evidence