Methyl chloroacetate → HCID 20061209, compound

Participants

Reaction Steps

1.5 g of 1,3-dimethyl-6-{2-[3-(4-nitroanilino)propylamino]ethylamino}-2,4(1H,3H)-pyrimidinedione (Compound b) obtained in the above procedure (3) were dissolved in 12 ml of DMSO, followed by the addition of 1.2 g of methyl chloroacetate and 1.5 ml of triethylamine. The resultant mixture was stirred at 50° C. for 2 hours, dissolved in chloroform, washed with water and then dried over anhydrous sodium sulfate. The solvent was thereafter distilled off under reduced pressure. The residue was purified by chromatography on a silica gel column (eluent: chloroform/methanol=30/1, by volume), thereby obtaining 1.8 g of 1,3-dimethyl-6-{2-[N-methoxycarbonylmethyl-3-(4-nitroanilino)propylamino]ethylamino}-2,4(1H,3H)-pyrimidinedione.

Provenance & Evidence