Water → HCID 20061220, compound

HRID 1085301Notes

Reaction equation

HRID 1085301 reaction equation
C1(C)C=CC(S(O[CH2:11][CH2:12][CH2:13][C:14]2[CH:19]=[CH:18][C:17]([N+:20]([O-:22])=[O:21])=[CH:16][CH:15]=2)(=O)=O)=CC=1.[CH:24]([NH2:27])([CH3:26])[CH3:25].O.C(Cl)(Cl)Cl>O1CCOCC1>[CH3:25][CH:24]([NH:27][CH2:11][CH2:12][CH2:13][C:14]1[CH:15]=[CH:16][C:17]([N+:20]([O-:22])=[O:21])=[CH:18][CH:19]=1)[CH3:26]

Participants

6

Reactant 4

HCID 962WaterHCID 6212Chloroform2×HCID 6363IsopropylamineHCID 12918159HCID 12918159, compound

Product 1

HCID 20061220HCID 20061220, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

3-(4-nitrophenyl)propyl p-toluenesulfonate (1 g) and 5 ml of isopropylamine were dissolved in 15 ml of dioxane, and the solution was stirred under heating with reflux for 4 hours. To the solution were added 100 ml of water and 100 ml of chloroform, and the mixture was thoroughly mixed for extraction. The chloroform-layer fraction was taken, washed with water and dried over sodium sulfate anhydrous. The solvent was removed in vacuo, and thus 0.61 g of an oil of N-(1-methylethyl)-3-(4-nitrophenyl)propylamine was obtained.

Workup

  1. temperatureunder heating
  2. temperaturewith reflux for 4 hours
  3. additionthe mixture was thoroughly mixed for extraction
  4. washwashed with water
  5. dry with materialdried over sodium sulfate anhydrous
  6. customThe solvent was removed in vacuo, and thus 0.61 g of an oil of N-(1-methylethyl)-3-(4-nitrophenyl)propylamine
  7. customwas obtained

Sources & evidence

ORD record
ord-b4a64176276949b38133af8f17bdd7b1
Source dataset
uspto-grants-1991_04
Patent number
US05008267

Reaction notes

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