Sodium Hydroxide → HCID 20061183, compound

Participants

Reaction Conditions

Reaction Steps

3-methoxy-4-nitrocinnamic acid (6.2 g) and 12.3 g of hydroxyamine sulfate were dissolved in 250 ml of water. To the solution was added 7.1 g of sodium hydroxide, and further alternately added a solution of 18 g of sodium hydroxide in water (27 ml) and 19.2 g of hydroxyamine-o-sulfonic acid little by little, maintaining the pH at 9. The mixture was stirred at 5° C. for 6 hours and then insoluble substances were removed by filtration. The resultant filtrate was cooled on ice and was added with 6 N sulfuric acid to adjust the pH to 2. Crystals formed were collected by filtration, washed with water and dried; 1.27 g of crystalline 3-(3-methoxy-4-nitrophenyl)propionic acid was thus obtained.

Provenance & Evidence