p-Toluenesulfonic acid monohydrate → HCID 20061408, compound

Participants

Reaction Steps

6-(1-aziridinyl)-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione (compound 6) (0.45 g), 0.7 g of N-(2-hydroxyethyl)-3-(3-methoxy-4-nitrophenyl)propylamine and 50 mg of p-toluenesulfonic acid monohydrate was dissolved in 25 ml of acetonitrile and then the solvent was removed in vacuo. The resultant oil was allowed to react at 80° C. for 3 hours and then subjected to silica gel column chromatograph (chloroform/methanol=40/1, v/v) for purification; thereby 0.38 g of an oil, 1,3-dimethyl-6-{2-[N-(2-hydroxethyl)-3-(3-methoxy-4-nitrophenyl)propylamino]ethylamino}-2,4(1H,3H)-pyrimidinedione, was obtained.

Provenance & Evidence