HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → (-)-(1R,2S)-2-phenylcyclohexyl chloroacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Chloroacetyl chloride | HCID 6577 | — |
| Reactant | rel-(1R,2S)-2-Phenylcyclohexanol | HCID 102793 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (-)-(1R,2S)-2-phenylcyclohexyl chloroacetate | HCID 14295383 | — |
Reaction Steps
In the next step, (±)-trans-2-phenylcyclohexanol is reacted with chloroacetyl chloride at reflux in a basic solvent such as a mixture of methylene chloride and pyridine or, more preferably, 4-dimethylaminopyridine and methylene chloride. The resulting (±)-trans-2-phenylcyclohexyl chloroacetate of the formula ##STR29## can be isolated by conventional means such as extraction followed by distillation of the organic layer.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05008411 |
| Source dataset | uspto-grants-1991_04 |
| ORD ID | ord-a3e42356f5aa4e7588e7b4d3943edfe1 |
| Source note | uspto-grants-1991_04 |