HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1085332Generated: October 31, 2026
Peracetic Acid → Methyl 2-(4-acetoxyphenoxy)propanoate
https://huagongshe.com/reaction/1085332
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Peracetic Acid | HCID 6585 | — |
| Reactant | Propanoic acid, 2-(4-hydroxyphenoxy)-, methyl ester | HCID 366926 | — |
| Reactant | Methyl 2-(4-acetylphenoxy)propanoate | HCID 14717334 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | Methyl 2-(4-acetoxyphenoxy)propanoate | HCID 20062087 | 71% |
Reaction Steps
To a solution of methyl 2-(4-acetylphenoxy)propanoate (5.6g, 25.0 mmol) in acetic acid (25 mL) is added peracetic acid (35%, 6.5g, 30.0 mmol) dropwise over 30 minutes at 25° C. The reaction is refluxed at 70° C. for 5 hours to give an orange-brown liquid. Acetic acid and residual peracetic acid are removed by high vacuum. The solution is kugelrohr distilled to give a light brown-orange product which contains methyl 2-(4-acetoxyphenoxy)propanoate (conversion 93%, selectivity 76%, yield 71%) and methyl 2-(4-hydroxyphenoxy)propanoate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05008439 |
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| Source dataset | uspto-grants-1991_04 |
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| ORD ID | ord-edfea0a34b65454da9995d06e33b4ba3 |
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| Source note | uspto-grants-1991_04 |
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