Hydrogen Peroxide → HCID 14820755, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl 2-(4-acetylphenoxy)propanoate (5.01 g, 21.0 mmol) is dissolved in acetic acid (10 mL) and Amberlyst-15(R) (0.24 g) added. Hydrogen peroxide (70%), 1.58 g, 33.0 mmol) is then charged dropwise over 30 minutes to the reaction. The reaction is refluxed for 8 hours at 45-60° C. and 57-60 mm HgA whereupon the reaction is analyzed by GLC. The reaction is cooled to room temperature and concentrated under reduced pressure to give ethyl 2-(4-acetoxyphenoxy)propanoate (4.72 g) (yield 88.3%).

Provenance & Evidence