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Potassium Carbonate → Methyl 2-(4-phenoxybut-1-yloxy)-phenylacetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | (4-Bromobutoxy)benzene | HCID 70986 | — |
| 反応物 | Methyl (2-hydroxyphenyl)acetate | HCID 89719 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Methyl 2-(4-phenoxybut-1-yloxy)-phenylacetate | HCID 14550847 | — |
反応手順
28.2 g (0.17 mole) of methyl 2-hydroxyphenylacetate, 25.8 g (0.19 mole) of potassium carbonate and 38.9 g (0.17 mole) of 4-phenoxybutyl bromide in 400 ml of dimethylformamide are stirred for 24 hours at 70° C. Thereafter, the solvent is stripped off and the residue is taken up in diethyl ether. The solution is extracted several times with water and saturated sodium carbonate solution and the organic phase is dried over MgSO4. The oil obtained after removal of the solvent is purified by chromatography over silica gel (cyclohexane/ethyl acetate). Yield: 31 g (58%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05008438 |
| 出典データセット | uspto-grants-1991_04 |
| ORD ID | ord-c21204cd35e44371820de599ad217de2 |
| 出典メモ | uspto-grants-1991_04 |