Triethylamine → 1-(1-Oxo-2-propenyl)-4-(phenylmethyl)piperazine

Participants

Reaction Steps

A solution of acryloyl chloride (4.52 g, 0.05 mole) in 25 ml of ethyl ether was added to a cold solution of 1-benzylpiperazine (8.8 g, 0.05 mole) and triethylamine (30 ml, 0.20 mole) in 500 ml of ethyl ether. A white precipitate formed. The reaction mixture was stirred overnight, filtered and the precipitate washed well with ethyl ether. The solvent and triethylamine were removed and the product chromatographed on silica, eluting with ethyl acetate/hexane [30:70 (v/v)] to yield 1.5 g of the title compound. The structure was confirmed by NMR.

Provenance & Evidence