HCID 10380252, compound → HCID 178462868, compound

Participants

Reaction Conditions

Reaction Steps

3.0 g (0.0099 mol) of Compound e obtained in Reference Example 4 was dissolved in 110 ml of acetic acid. 0.89 g of 10% palladium carbon was added to the solution. Under hydrogen stream, the solution was stirred 3 hours at 70° C. After filtration, the filtrate was concentrated under reduced pressure. Anhydrous sodium carbonate was added to the solution for neutralization, and a precipitate was collected by filtration and recrystallized from isopropanol-water, to afford 2.0 g (yield: 93%) of Compound h.

Provenance & Evidence